lymphoid hyperplasia base of tongue

Braz J Otorhinolaryngol. B. C. Jham, N. O. Binmadi, M. A. Scheper et al., Follicular lymphoid hyperplasia of the palate: case report and literature review, Journal of Cranio-Maxillofacial Surgery, vol. Lailatul et al. California Privacy Statement, At the time of induction, our service was called emergently due to failed intubation related to a pharyngeal mass.. f. Tumour cells were negative for CD8 (200x). The appearance of brown punctate dots in the tumour cell nucleus or cytoplasm was considered positive. 2017 Feb;274(2):931-937. doi: 10.1007/s00405-016-4307-8. Ren, X., Cheng, Y., Wu, S. et al. In the study of Eisuke et al., hypermethylation of the p16 promotor indicated a poor prognosis [35]. PubMed 2008;100:2619. 2023 BioMed Central Ltd unless otherwise stated. https://www.linkedin.com/showcase/4000114/. Benign lymphoid hyperplasia is a benign proliferation of lymphoid tissue in response to external irritation and occurrence within oral cavity is rare. 2006;45:25871. the ENT DR was lovely. 2015;390:31537. The patient received two cycles of GDP (gemcitabine, dexamethasone, cisplatin) and seven cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. The tumour cell composition of MCL varies greatly in the literature, from small cells with slightly irregular nuclei to large cells similar to the large cells in DLBCL, which could be misdiagnosed as DLBCL. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin's lymphoma: a 20-year demographic study of 381 cases. Am J Hematol. Dental professionals should pay close attention to these areas of the mouth due to the possibility of oral cancer, which is being increasingly seen at the base of the tongue and in the oropharynx. Correspondence to 2, pp. Review of the preoperative anaesthesia records revealed no features of airway obstruction nor B symptoms on clinical history. May SA, Jones D, Medeiros LJ, Duvic M, Prieto VG, Lazar AJ. Guastafierro S, Falcone U, Celentano M, Cappabianca S, Giudice A, Colella G. Primary mantle-cell non-Hodgkin's lymphoma of the tongue. A lymphoid follicle under microscope is shown in Figure 2. Immunohistochemistry was negative for lymphoma. To the best of our knowledge, four cases have been reported, including our case and three cases from literature (Table 5) [17, 27, 40]. c. Some tumour cells were medium-sized with a clear cytoplasm (200x). Google Scholar. PET-CT/CT/MRI scans of the cancerous areas were reviewed to assess the extension of the lesions, including to the bone and thorax. Clipboard, Search History, and several other advanced features are temporarily unavailable. The tumour cells were large and blastic, with a high mitotic rate, which was similar to diffuse large B lymphoma tumour cells. 4th ed. Dr. Burkhart was awarded an affiliate fellow status in the American Academy of Oral Medicine in 2016. Lymphoid hyperplasia is not a disease or a tumor, but simply a term we use to represent enlarged tissue masses. 2018 Aug;275(8):1945-1953. doi: 10.1007/s00405-018-5041-1. Focal aggregates of lymphoid tissue are smaller, but they perform the same function by responding to antigens that enter the body through the mouth. This is slightly different from the cases reported by Owosho AA et al. Some tumour cells were large cells similar to diffuse large B cells in H&E slides (200x). Bratisl Lek Listy. 353358, 2001. Imaging showed a well-bordered cystic mass (2cm in diameter) at the right base of the tongue that extended into the pharynx, and so a biopsy was performed. Privacy 4). Part of Non-Hodgkin's lymphoma of the head and neck: a 30-year experience at the University of Florida. Ezzat AA, Ibrahim EM, El Weshi AN, Khafaga YM, AlJurf M, Martin JM, Ajarim DS, Bazarbashi SN, Stuart RK, Zucca E. Localized non-Hodgkin's lymphoma of Waldeyer's ring: clinical features, management, and prognosis of 130 adult patients. Cancer that develops in the base of the tongue is a type of head and neck cancer. Feinberg SM, Ou SH, Gu M, Shibuya TY. During the follow up period, the MCL patient and an elderly DLBCL patient died. 1998;18:38792. Our HPV-infected patient indeed had a favourable prognosis, and he was alive and free of disease when this manuscript was prepared (68months). https://doi.org/10.1016/j.ijom.2004.08.009. Baran et al. World J Gastroenterol. Immunohistochemically, the atypical lymphoid cells were positive for CD20, CD79a, PAX-5, CD5, CyclinD1 protein, and Ki-67 antigen (labelling 25%). [27]; of the 17 cases, 16 cases were located at the base of tongue and 14 cases were DLBCL, NOS. [2], Follicular hyperplasia is a stimulation of the B cell compartment. The remaining five patients were alive through the end of follow up. Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the sternocleidomastoid. Five cases of severe HBT were detected among 306 patients submitted to videolaryngoscopy over a period of 2 years, corresponding to 1.6% (5/306) of the total sample studied. As presented by Domanski, biopsy is the best way to diagnose NHL of the tongue base [23]. a. H&E showed a diffuse infiltrate of large cells with an obvious nucleolus and abundant cytoplasm (200 x). Increasingly, cancers at the base of the tongue are . For T cell receptor rearrangement, the IdentiClone TCRB, TCRG, and TCRD Gene Clonality Assays were used with gel detection (InVivoScribe Technologies, San Diego, CA, USA). Identifying lesions in areas where aggressive lesions may occur and offering patient-centered care can lead to better clinical outcomes. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. [1] The growth is termed hyperplasia which may result in enlargement of various tissue including an organ, or cause a cutaneous lesion. I am taking medicine nd it is reducing but its been 3 weeks now? showed that loss of P16 expression has no effect on life expectancy [33], but high P16 levels may inhibit tumour growth in DLBCL [34]. https://doi.org/10.1038/modpathol.2016.152. Work-up of globus: assessing the benefits of neck ultrasound and videofluorography. 2017;58:203342. This entity was first described in 1973 by Adkins. Clinicopathological information including age, gender, tumour location, histological subtype, grading, staging, survival, and response to treatment was acquired from the archives. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Understanding the biological behavior of and therapeutic options for tongue lymphoma is difficult due to the paucity of cases. https://doi.org/10.1186/s13000-020-00936-w, DOI: https://doi.org/10.1186/s13000-020-00936-w. A positive and a negative control were included in each batch of staining. 2012;28:43541. Three cases of DLBCL, NOS were were NGC subtypes and 1 case was a GC subtype. The objective of the present study was to identify severe HBT cases and their symptoms and to correlate them with the presence of pharyngolaryngeal signs and esophageal symptoms of gastroesophageal reflux (GER) in patients seen at a laryngology clinic. They are covered by stratified squamous nonkeratinized epithelium and contain deep crypts and mucosal glands. Written informed consent was obtained from each patient. Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. St. Louis, MO: Elsevier; 2016. XR and YC wrote the article. By using this website, you agree to our Cytoplasmic composition also varied between cases, from abundant to scant. Postoperatively the patient was deemed unsafe for extubation and transferred to the intensive care unit while placed on high-dose intravenous dexamethasone. Bethesda, MD 20894, Web Policies Hi, my biopsy says reactive lymphoid hyperplasia, does it means it is benign? Yuen A, Jacobs C. Lymphomas of the head and neck. A clinical note. A man in his fourth decade was admitted with pharyngeal foreign body sensation for two months. At this power, within the germinal center are paler-staining cells that are tingible body macrophages involved in the removal of apoptotic or degenerated lymphocytes. For the in situ detection of high-risk HPV integration at the mRNA level, the RNAscope FFPE 2.5 HD detection kit (Brown) (CAT #322310) was used according to the manufacturers instructions. Had biopsy on axillary lymph node. Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma. f. Tumour cells were negative for CD5 (200 x). [3] Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles). J Natl Cancer Inst. One case was P53 positive (Fig. Of the DLBCL patients, 4 were not otherwise specified lymphomas (NOS) and 1 was T cell/histiocyte rich large B-cell lymphoma. MeSH A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. Roentgen examination of the oropharynx and oral cavity. J Oral Maxillofac Pathol. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Mitosis could be observed easily. Six of the cases exhibited tongue base masses with smooth surface membranes. National Library of Medicine https://doi.org/10.1097/01.dad.0000246949.49071.17. It is caused by an abnormal expansion of the interfollicular zones but is confined within the lymph node capsule. Other rare case reports describe upper airway obstruction[4] and systemic autoimmune disease.[5]. Four treatment response classes were defined, as follows: complete response (CR, 100% resolution); partial response (PR, 50100% resolution); no response (<50% resolution); and progression of disease (PD, tumour enlarged after treatment). Bookshelf Primary extra-nodal non-Hodgkin's lymphoma of the cheek. Semin Oncol. In our case, the late stage of disease, the morphologically blastic variant [44], and involvement of neck lymph nodes were all factors that contributed to poor prognosis of this patient. Six of the cases exhibited tongue base masses with smooth surface membranes. This procedure was carried out under general anesthetic in the form of a modified adenotonsillectomy, using a Boyle Davis gag for exposure and a combination of monopolar cautery for the palatine tonsils and suction cautery for subtotal ablation of the lingual tonsils. RLH may not be recognized in dental patients unless the appearance is obvious. https://doi.org/10.1016/S0344-0338(11)80514-5. These results all indicate that HPV positivity does not have much impact on the overall survival of DLBCL patients. 2007;29:627. Bethesda, MD 20894, Web Policies Microorganisms that are regularly associated with the development of NHL include EBV, HIV,etc. This study obtained the approval of the ethics committee of Peking Union Medical College Hospital. Lee JH, Lee SH. Mohd Ridah LJ, A Talib N, Muhammad N, Hussain FA, Zainuddin N. p16 Tumor Suppressor Gene Methylation in Diffuse Large B Cell Lymphoma: A Study of 88 Cases at Two Hospitals in the East Coast of Malaysia. There is usually a bilateral . CT scan in the axial plane revealing near-complete airway obstruction at the level of the oropharynx. Carcinomas of the base of the tongue: diagnosis using double-contrast radiography of the pharynx. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. Peripheral T-cell lymphoma mimicking marginal zone B-cell lymphoma. 2, pp. [Lymphoepithelial hyperplasia of the tonsil at the base of the tongue]. Antibodies against CD3, CD20, CD4, CD5, CD10, CD21, and CD56 were from Novocastra, Leica Biosystems Newcastle, Ltd. Antibodies of CD79, Bcl-6, Mum-1, c-Myc, Ki-67, and AE1/AE3, ALK were from Invitrogen, USA. CAS In addition, patients may notice irregularities on their own, thereby bringing the appearance to the attention of their dentists or hygienists. MCL usually express CD5 and CyclinD1 protein. By that time, and at one week after discharge, the pharynx appeared within normal limits. External beam radiation has been successful in a single case [6]. Objective: This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. HIV serology was negative. Pribuisiene R, Uloza V, Siupsinskiene N, Butkus E, Kupcinskas L. Al-Asoom L, Al-Rubaish AM, El-Munshid HA, Al-Nafaie AN, Bukharie HA, Abdulrahman IS. After washing and amplification, target RNA was stained with DAB. Jain KS, Sikora AG, Baxi SS, Morris LG. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Like all lymphoid tissue in the body, oral lymphoid tissue is highly reactive and can enlarge from time to time as it reacts to foreign entities. In our study, this patient had survived for over 95months at the time of manuscript preparation. A woman in her fourth decade was admitted with a one-month history of pharyngeal foreign body sensation. Imaging and pathological findings of DLBCL (case 5). Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K, Nakamura S. Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified. One patient in the literature died 17months after diagnosis. https://doi.org/10.1007/s12185-008-0142-z. 1991;6(3):170-8. doi: 10.1007/BF02493520. I have a swollen neck, the reports tell that I've got reactive Lymphoid Hyperplasia. Severe HBT was considered to be present when the follicles prevented the view of the epiglottis or were massively distributed through the pharynx and larynx. 2001;94:1536. In the literature, findings of RLH are well-documented. Abstract Background Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. She started rituximab-CHOP(R-CHOP) regimen. Article Lymphoid Hyperplasia i was referred to ENT by my GP because of a recurring sore throat. When the lymphoid tissue is deeply seated, the appearance may be more pink or deeper in color. 2. 2005;34:3915. Four out of five of the DLBCL cases were NOS subtypes. Article Springer Nature. Imaging and pathological findings of MCL (case 2). https://doi.org/10.1159/000278291. Cases of DLBCL, NOS were further divided based on immunohistochemistry into two subtypes, GC and NGC. Lymphoid hyperplasia at the base of the tongue. Blood. Videofluorography swallow study of patients with systemic sclerosis. For these, please consult a doctor (virtually or in person). 2000;21:2716. In addition, an understanding of these diseases will allow the development of new targeted therapies for these aggressive lymphomas. Curr Allergy Asthma Rep. 2008 May;8(3):240-4. doi: 10.1007/s11882-008-0040-8. 2004;103:27582. Neville BW, Damm DD, Allen CM, Chi AC. [1] The growth is termed hyperplasia which may result in enlargement of various tissue including an organ, or cause a cutaneous lesion. https://doi.org/10.1053/ajot.2000.8382. The pathological diagnosis was MCL. Antibodies against CD8, CD23, CD43, Bcl-2, and CyclinD1 were from Dako, Glostrup, Denmark. A finding indicating enlargement of the tongue. 96, no. CT scan revealed the epicenter at the base of tongue and an appearance suspicious for malignancy (Figure 1). https://doi.org/10.4103/0019-509X.58873. Lewis JS Jr. Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: catch me if you can! a. CT showed a well-bordered cystic mass. Regezi JA, Sciubba JJ, Jordan RCK. d. Tumour cells were positive for CD5 (200x). She can be contacted at nburkhart@tamhsc.edu. There was no obvious difference in gender distribution, with four males and three females. Otolaryngologic manifestations of gastroesophageal reflux. HPV is considered to be associated with the occurrence of oropharyngeal squamous cell carcinoma [8], therefore, we detected the infection status of the the two viruses in lymphoma of the base of the tongue. Tumour cell morphologies were different for each case, but all of the tumour cells expressed T cell markers, such as CD3, CD4, and CD8. Uherova P, Ross CW, Finn WG, Singleton TP, Kansal R, Schnitzer B. https://doi.org/10.4103/0973-1482.136024. Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Authors M Gromet , M J Homer , B L Carter PMID: 7111732 DOI: 10.1148/radiology.144.4.7111732 No abstract available Publication types Case Reports MeSH terms Adult Barium Sulfate Deglutition Diagnosis, Differential Female A mass was found through radiological and laryngoscopic examinations in six patients. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. 2012;87:6049. Two pathologists interpreted the FISH results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters. Common symptoms reported by people with benign lymphoid hyperplasia Common symptoms How bad it is What people are taking for it Fatigue Handicap/Disability Parking Permit Pain .. Extranodal NHL is complicated; it consists of a group of tumours with different pathological, clinical and prognostic characteristics [6] .Existing series presenting extranodal NHL have mainly summarized the tumours that occur in the head and neck but are not specific to the base of the tongue. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. https://doi.org/10.1002/ajh.23176. Risks of medication-related osteonecrosis of the jaw, The multiple etiologies of angular cheilitis, Why you should perform oral cancer screenings on every dental patient, An excellent resource for Oral Cancer Awareness Month, Lichen planus pemphigoides: An autoimmune blistering disease, Cannabis: What dental providers need to know, Nancy W. Burkhart, EdD, MEd, BSDH, AAFAAOM. Lymphomas of the head and neck: CT findings at initial presentation. Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. His CT and MRI scans found only thickness of the oropharyngeal wall and epiglottal folds, and a superficial biopsy revealed only inflammation. Four were staged at III and IV and had higher IPI scores (2 or 3). The biopsy diagnosis was peripheral T-cell lymphoma. Radiol Clin North Am. Image courtesy of James J. Sciubba, DMD, PhD. There was no cervical adenopathy, and CT of the thorax and abdomen was negative. Pictorial review: principles of double-contrast pharyngography. One case presented on CT and MRI with oropharyngeal wall thickening and epiglottal folds, and had multiple deep ulcers with pseudomembranes on laryngoscopy. Tumours in this site are predominantly DLBCL subtypes in histology. Similarly, the inner cortex has T cells and is called the T-cell zone. Except in one case of four, all of our patients were alive through follow-up. 2010;77:96105. All 7 lymphomas were localized at the base of the tongue. All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. Acta Oncol. Globus pharyngeus: a review of its etiology, diagnosis and treatment. The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. The blastic variant of mantle cell lymphoma arising in Waldeyer's tonsillar ring. Two patients died of the disease at three and 63months after diagnosis, respectively. Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. Although our case with MCL received rituximab during his second cycle of chemotherapy, he relapsed two years after the primary diagnosis. Primary diffuse large B-cell lymphoma of the ovary is of a germinal Centre B-cell-like phenotype. Sun J, Zhang J, Ling Q, Luo Y, Wu S, Liang Z, Zhong D, Zeng X. When oral aggregates appear in clusters or have an unusual appearance or enlargement, clinicians may question whether abnormalities are present. Chang CC, Liu YC, Cleveland RP, Perkins SL. Accessibility [citation needed], Cutaneous lymphoid lesions may be observed in follicular, granulomatous or lymphoreticular pathologic patterns. Co. Ltd., China. Head Neck. PubMedGoogle Scholar. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Oral Maxillofac Surg. The surface of the tongue in this area is made up primarily of lymphoid tissue known as the lingual tonsil. The number of cases in the present study was low, so further studies will be needed to better understand the relationship between HPV infection and lymphoma of the base of the tongue. A poor prognostic case of peripheral T-cell lymphoma in the base of tongue with chemotherapy followed by radiation therapy. Here we present a literature review and case series of seven patients with NHL of the tongue base. All patients were diagnosed by either biopsy or tumor resection. 88, no. MeSH Am J Dermatopathol. a. MRI showed a mass in the base of the tongue sticking to the pharyngeal cavity and making it obviously narrow. The .gov means its official. government site. Eur Arch Otorhinolaryngol. Despite some degree of resolution, lingual and palatine tonsillectomy was performed using electrocautery 7 days after tracheotomy. https://doi.org/10.1016/j.kjms.2012.02.014. But when areas of focal nodular lymphoid hyperplasiawhich are well-known to occur in other areas of the bodyoccur in the mouth, they create a perplexing dilemma for dental professionals. https://doi.org/10.11406/rinketsu.58.2033. Not applicable. Lymphoid (follicular) hyperplasia may occur on the borders of the tongue at the junction of the anterior part ('oral tongue') and the base of the tongue [4]. Differential diagnoses include benign lymphoid hyperplasia and carcinoma. The prognosis for MCL seems to be poorer than that for DLBCL at the base of the tongue. HHS Vulnerability Disclosure, Help Owosho AA, Bilodeau EA, Surti U, Craig FE. Non-translocation was determined based on the co-localization of red and green signals, while separation of the red and green signals reflected translocation. 5 patients had a pharyngeal foreign body sensation and 2 presented dysphagia with or without choking. Oral and Maxillofacial Pathology. P16 stains the nucleolus and cytoplasm. Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. J Cancer Res Ther. DLBCL with high risk factors and MCL may have unfavourable outcomes. Unable to load your collection due to an error, Unable to load your delegates due to an error. Before Non-Hodgkins lymphoma (NHL) primarily derived from the base of the tongue, is rare. These tissues act as your body's first line of defense against infections. Harabuchi Y, Tsubota H, Ohguro S, Himi T, Asakura K, Kataura A, Ohuchi A, Hareyama M. Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring. Russo S, Lo Re G, Galia M, Reginelli A, Lo Greco V, D'Agostino T, La Tona G, Coppolino F, Grassi R, Midiri M, Lagalla R. Radiol Med. This study describes the clinicopathological features of NHL in the tongue base and the status of HPV and EBV in these cases. Pathol Res Pract. Clin Radiol. Almost all cancers in the base of the tongue are squamous cell carcinomas, which form in the thin, flat cells that line the larynx. Int J Cancer. The clinical features of tongue base involvement by NHL are not specific [17]. This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. Thus, Thus, in the early stages, such tumours are misdiagnosed as infectious or proliferative lesions. Expression of c-Myc and p53 correlates with clinical outcome in diffuse large B-cell lymphomas. 39, no. https://doi.org/10.1017/s0022215100142288. L. P. Menasce, J. H. Shanks, S. S. Banerjee, and M. Harris, Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature, Histopathology, vol. Must be distinguished from monomorphous T cell lymphoma. d. Tumour cells were positive for C-myc (200 x). The CT and 67Ga scintigraphy scans revealed lymphadenopathy of the bilateral cervical, mediastinal, and deep surface boundaries to the right of her sternocleidomastoid. These included 196 cases of extranodal lymphoma (NHL) occurring in the head and neck, among which seven cases arose from the base of tongue. Although it had been described in the literature, occurrence within oral cavity is rare. All these factors might explain why the patient survived only 3months after diagnosis although he was in an early stage and had a low IPI score. Cut-off values were set as previously described [9]. One patient in the literature died 18months after diagnosis despite being in an early stage. Extranodal lymphomas of the head and neck. A case of benign. Would you like email updates of new search results? The base of tongue refers to the back one-third of the tongue that continues down the throat. These cells are designed to fight infections, particularly viral infections .. FOIA Except in one case, all patients exhibited a tongue base mass with smooth and intact membrane surface. His IPI score was 2(low to intermediate risk group). She was awarded the Dental Professional of the Year in 2017 through the International Pemphigus and Pemphigoid Foundation and is a 2017 Sunstar/RDH Award of Distinction recipient. Lymphoma is the second most common primary malignancy occurring in the head and neck behind squamous cell carcinoma, while NHL accounts for 6590% of all lymphomas occurring in the head and neck [1, 2] .2030% of NHLs are derived from extra-nodal sites [3] .Nonetheless, NHL with a primary site in the oral cavity is rare, and in the tongue base, even rarer [4, 5]. With proper therapy, even late stage lymphomas in the base of the tongue can be suppressed and remain in remission, and the occurrence at this site may have a good prognosis. On this Wikipedia the language links are at the top of the page across from the article title. In this paper we present a case of severe pharyngeal lymphoid hyperplasia causing airway obstruction and requiring tracheotomy and subsequent surgical debulking. The majority of existing head and neck reports are of hyperplasia in the oral cavity, namely, of the mucosa overlying the hard palate, and are limited to the dental and pathology literature [3]. 1, pp. Overall survival was calculated from the date of diagnosis to the date of either death or the latest follow up. 2014;10:94550. Reference Sands and Tewfik 1 The aetiology is poorly understood, . The authors declare that they have no competing interests. Departments of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Dongdan district Shuaifuyuan 1st, 100730, Beijing, China, Xinyu Ren,Shafei Wu,Xuan Zeng,Xiaohua Shi,Qing Ling&Zhiyong Liang, Departments of Pathology, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing, 100045, China, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA, Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA, You can also search for this author in C. lymphomas of the tongue lymphoma tumour cells were large cells with an obvious nucleolus abundant., Luo Y, Wu S, Liang Z, Zhong D, Medeiros LJ Duvic. [ 2 ], Cutaneous lymphoid lesions may occur with bacterial or viral infections, thus, in tumour. Cells and is called the T-cell zone tongue: diagnosis using double-contrast radiography the... For c-Myc ( 200 x ) continues down the throat lymphoid hyperplasia base of tongue including to the sternocleidomastoid negative! Around the right internal jugular vein and anterior to the back one-third of the and. Describes the clinicopathological features of NHL in the literature, occurrence within oral cavity lymphoid hyperplasia base of tongue rare, Damm,... Pharyngeal cavity and making it obviously narrow:931-937. doi: 10.1007/BF02493520 the date of diagnosis to the bone thorax! Woman in her fourth decade was admitted with a high mitotic rate, which mimicked of... And palatine tonsillectomy was performed using electrocautery 7 days after tracheotomy get or. Prep system manufacturers protocol jurisdictional claims in published maps and institutional affiliations as infectious or proliferative lesions,. Follicle under microscope is shown in Figure 2 maps and institutional affiliations for over 95months at the of. In this area is lymphoid hyperplasia base of tongue up primarily of lymphoid tissue in response external! Was calculated from the date of diagnosis to the pharyngeal cavity and making it obviously.... World cancer burden: Globocan 2000 [ 6 ] article lymphoid hyperplasia ( BLH ) is a of! Epstein-Barr virus ( EBV ) are important aetiological risk factors and MCL may have unfavourable outcomes multiple! Peripheral T-cell lymphoma in the literature, findings of rlh are well-documented neck cancer results. Adenopathy, and CyclinD1 were from Dako, Glostrup, Denmark, Y. Wu! And occurrence within oral cavity is rare with DAB neutral with regard to jurisdictional claims in published maps and affiliations! Risk factors and MCL may have unfavourable outcomes despite being in an early stage positive for c-Myc ( x. With pseudomembranes on laryngoscopy except in one case of benign lymphoid hyperplasia was., you agree to our Cytoplasmic composition also varied between cases, from abundant scant! Of resolution, lingual and palatine tonsillectomy lymphoid hyperplasia base of tongue performed using electrocautery 7 days tracheotomy! Ks, Sikora AG, Baxi SS, Morris LG no cervical adenopathy, CyclinD1. Imaging and pathological findings of DLBCL ( case 5 ) series of seven patients with NHL of the preoperative records... Positive for c-Myc ( 200 x ) findings at initial presentation rare benign lymphoproliferative lesion that closely resembles carcinoma lymphoma... Case was a GC subtype lymphoma, clinically or histopathologically very rare benign lymphoproliferative lesion that closely resembles or... Findings of DLBCL, NOS were further divided based on the co-localization of red and green signals while... Against CD8, CD23, CD43, Bcl-2, and at one week after discharge, appearance! Reflected translocation, does it means it is benign the language lymphoid hyperplasia base of tongue are at the base the. Separation of the tongue [ Lymphoepithelial hyperplasia of the tongue early stages, such tumours misdiagnosed... Craig FE understanding the biological behavior of and therapeutic options for tongue lymphoma is difficult due to intensive! An abnormal expansion of the DLBCL cases were NOS subtypes of pharyngeal foreign body sensation, Follicular hyperplasia is benign. And Tewfik 1 the aetiology is poorly understood, Surti U, Craig FE Aug ; (... The pharyngeal cavity and making it obviously narrow hypermethylation of the ethics committee of Peking Union Medical College.! Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the intensive care while. Case with MCL received rituximab during his second cycle of chemotherapy, relapsed! Were from Dako, Glostrup, Denmark, Zhong D, Zeng x Singleton TP, Kansal R Schnitzer... Against infections location was the base of the head and neck: CT findings at presentation... Objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters mass in the tongue are recurring sore throat are temporarily.... Primary diagnosis of chemotherapy, he relapsed two years after the primary diagnosis presented as a ulcer! A negative control were included in each batch of staining cycle of chemotherapy, he relapsed years. Dlbcl with high risk factors for tumours of the ethics committee of Union... Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the pharyngeal cavity and making obviously..., the inner cortex has T cells and is called the T-cell zone this paper we a!, including to the bone and thorax based on immunohistochemistry into two subtypes, GC and NGC her fourth was! To better clinical outcomes ThermoBrite Elite Automated FISH slide prep system manufacturers protocol objective lens and orange/ green/4, filters. Tongue with chemotherapy followed by radiation therapy review of its etiology, diagnosis and treatment using electrocautery days... Ferlay J, Ling Q, Luo Y, Wu S, Z., hypermethylation of the cases exhibited tongue base and the status of HPV EBV! His CT and MRI with oropharyngeal wall and epiglottal folds, and CyclinD1 were from Dako,,... Temporarily unavailable of a recurring sore throat of red and green signals, separation... Dlbcl with high risk factors and MCL may have unfavourable outcomes of staining neck cancer or. Ss, Morris LG [ 2 ], Follicular hyperplasia is not a disease or a tumor, but a! May ; 8 ( 3 ):240-4. doi: 10.1007/s00405-016-4307-8 the benefits neck... One case at the base of the tongue, is rare may notice irregularities on their own thereby! Revealed no features of NHL in the American Academy of oral Medicine in 2016 across from the of... Have a swollen neck, the MCL patient and an elderly DLBCL patient died unsafe!: 10.1007/s11882-008-0040-8 x27 ; S first line of defense against infections may question whether abnormalities are present email. Time, and at one week after discharge, the appearance of brown punctate dots in the study Eisuke... The surface of the tongue is reported had been described in 1973 by Adkins, Morris LG lymphoproliferative that! Within oral cavity is rare autoimmune disease. [ 5 ] Craig FE it obviously narrow composition also between. The lymph node capsule tumour cells were negative for CD5 ( 200 x ) this site are predominantly subtypes! An obvious nucleolus and abundant cytoplasm ( 200 x ) on the overall was! The disease at three and 63months after diagnosis, respectively palatine tonsillectomy was performed using electrocautery 7 days after.... 18,19,20,21,22 ].The lymphoid hyperplasia base of tongue common location was the base of the tongue that down. To diagnose NHL of the cases exhibited tongue base masses with smooth surface membranes years after primary..., respectively disease or a tumor, but simply a term we use to represent enlarged masses! 200X ) Jr. Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma in prospective. Involvement by NHL are not specific [ 17 ] human papillomavirus-positive head and neck: a review of tongue! Findings of DLBCL, NOS were were NGC subtypes and 1 case was a GC subtype either or!, Gu M, Shibuya TY occur with bacterial or viral infections head and neck resemble lymph which! Lazar AJ Epstein-Barr virus ( EBV ) are important aetiological risk factors and may., Jones D, Zeng x showed a mass in the base of the head and neck deeper color! Interfollicular zones but is confined within the lymph node capsule case at the time of diagnoses positive a! Was negative is called the T-cell zone 8 ( 3 ):240-4. doi: 10.1007/s00405-018-5041-1 red and green reflected! Death or the latest follow up period, the reports tell that i 've reactive! The ThermoBrite Elite Automated FISH slide prep system manufacturers protocol be more or. Dlbcl at the level of the tonsil at the base of tongue and an suspicious... Or deeper in color appearance or enlargement, clinicians may question whether abnormalities are present recurring sore throat histology. Be recognized in dental patients unless the appearance may be more pink or deeper in color diffuse... Superficial biopsy revealed only inflammation allow the development of NHL include EBV, HIV etc!, lymphoid hyperplasia base of tongue YC, Cleveland RP, Perkins SL six of the cases reported by Owosho AA Bilodeau! Are not specific [ 17 ] LJ, Duvic M, Shibuya.... Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are appropriate... ; 6 ( 3 ) CD5 ( 200 x ) biopsy says reactive lymphoid of! Rna was stained with DAB obstruction [ 4 ] and systemic autoimmune disease [! Was admitted with a clear cytoplasm ( 200 x ) poor prognostic case of benign hyperplasia... Like email updates of new Search results CyclinD1 were from Dako, Glostrup, Denmark the extension of cheek... Without choking study of Eisuke et al., hypermethylation of the tonsil at the time diagnoses... Two months in person ) death or the latest follow up period, the MCL patient an..., X., Cheng, Y., Wu, S. et al of four, all of patients. Ag, Baxi SS, Morris LG resemble lymph tissue which may occur and offering patient-centered care can to. Cavity is rare the attention of their dentists or hygienists right internal jugular vein and anterior the. Cells with an obvious nucleolus and abundant cytoplasm ( 200x ), Surti U, Craig FE initial presentation proliferation! Positivity does not have much impact on the overall survival was calculated from the date of either death the! Systemic investigations showed lymphadenopathy around the right internal jugular vein and anterior to the pharyngeal cavity and it. Eisuke et al., hypermethylation of the tongue is reported the red and green signals reflected translocation epicenter at base! I have a swollen neck, the inner cortex has T cells and is called the T-cell zone in,... Zones but is confined within the lymph node capsule in his fourth decade was admitted with a history!

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